Head injury and trauma are the leading causes of death and disability amongst the young, active population in Australia. Our trauma teams are engaged in research investigating all aspects of trauma care from pre-hospital care to determining the microenvironment dynamics in the wound to longitudinal health outcomes.

With the Australian Defence Force joining our centre, research in military trauma medicine has expanded, particularly in the treatment of traumatic coagulopathy, traumatic brain injury, pulmonary contusion and trauma systems design. Much of this work will also benefit civilian patients, particularly those in rural hospitals.

Current projects

  • Micro-environment analysis of traumatic wounds using microdialysis to determine molecular and biochemical markers and antibiotic concentrations. Wullschleger M, Roberts J, Pollard C, Lipman J, Tetsworth K, Upton Z Funder: RBWH 
  • Post-Concussion Syndrome: A longitudinal investigation of patient outcomes following mild traumatic brain injury. Greenslade J, Sullivan K, Edmed S.Funder: RBWH
  • Tranexamic acid blood levels in patients achieved using CRASH-2 dosing: the PATCH-LEVELS study. Reade M, Lipman J, Wallis S, Gruen R. Funder: ICF   
  • Diggers to Veterans: risk, resilience and recovery in the First AIF. McCalman J, Kippen R, Reade M, Shanks D, Hopper D. Funder: Australian Research Council (ARC)
  • Prehospital Antifibrinolytics for Traumatic Coagulopathy associated with Haemorrhage (The PATCH Study). Gruen R, Mitra B, Bernard S, Jacobs I, Medcalf R, Reade M, Tran H. Funder: NHMRC 
  • Epidemiology of pyroglutamic acid concentrations in the blood of critically ill patients. Reade M, Ungerer J. Funder: RBWH Foundation
  • Evaluation of cryopreserved platelets for the treatment of perioperative haemorrhage. Reade M, Holley A, Irving D, Marks D, Johnson L, Fraser J, Bellomo R, Gattas D. Funder: ANZCA, Australian Red Cross Blood Service (ARCBS) 
  • Prehospital Antifibrinolytics for Traumatic Coagulopathy associated with Haemorrhage (The PATCH Study). Gruen R,  Mitra B,  Bernard S,  Jacobs I,  Medcalf R,  Reade M, Tran H. Funder: NHMRC
  • Australian Research Council Discovery Project DP150100682. Diggers to Veterans: risk, resilience and recovery in the First AIF. McCalman J, Kippen R, Reade MC, Shanks D, Hopper D. 
  • National Institute for Health Research, UK. Alpha 2 agonists for sedation to produce Better outcomes from critical illness (A2B Trial): A randomised, parallel-group, allocation concealed, controlled, open, phase 3 pragmatic clinical and cost effectiveness trial with internal pilot. Walsh T, McKenzie C, Lone N, Aitkin L, Parker R, Kydonaki C, Reade MC, Dark P, Gordon A, Morris S, McAuley D, Weir C, Blackwood B, Page V, Perkins G.
  • A prospective, multicentre, randomised, double-blind placebo controlled, stratified phase III trial of EPOetin alfa vs. placebo in critically ill TRAUMA patients (EPO-TRAUMA). French C, Nichol A, Bellomo R, Cooper DJ, Bailey M, Higgins A, McArthur C, Reade MC, Duranteau J, Gabbe B, Pettila V, Skrifvars M, Napolitano L, Rosenfeld J.
  • European Society of Intensive Care Medicine. An international prospective observational StudY on iNtrAcranial PreSsurE in intensive care (ICU): the SYNAPSE study. Australian national co-ordinator.

 

Researchers