The Royal Brisbane and Women's Hospital Departments of Intensive Care Medicine, and Trauma Medicine together with the BTCCRC are site investigators for the following single and multi-centre trials.
Current
PROMOTE: A study investigating the variation in the management of patients with subarachnoid hemorrhage nationwide. Principal Investigator: J Cohen.
INFARCT: A study of inflammation and augmented renal clearance in traumatic brain injury. Principal Investigators A Udy, J Lipman and J Roberts.
ADRENAL-GEPS: A study profiling gene expression in critically ill patients with septic shock. Principal Investigators D Evans and J Cohen.
VTE AUDIT: A point prevalence survey of venous thromboembolism prophylaxis management in the critically ill and an epidemiological observational audit of venous thromboembolism prophylaxis management in critically ill patients with severe sepsis. Principal Investigator J Gowardman.
DRIP: A study to develop a research base for intravenous peripheral catheter resites.
SAVED: A study of practices and complications associated with central venous and arterial catheterization in an ICU population. Principal Investigators: J Gowardman and C Rickhard.
SuDDICU: An exploratory study of perceived risks, benefits and barriers to the use of Selective Decontamination of the Digestive Tract in Australasian ICUs. Principal Site Investigator: J Lipman.
Heparin: A dosing study investigating low molecular weight heparin in critically ill trauma patients. Principal Site Investigator: J Lipman.
i-PERFORM: A trial investigating physiological and functional outcomes following early habilitation in sepsis patients. Principal Investigators: G Kayambu, J Paratz, R Boots.
Sepsis: A randomized controlled trial: Improving outcomes in sepsis. Principal Investigators: R Boots, J Paratz, J Kenardy.
eStimCycle: A novel intervention to improve outcomes in the critically ill: Functional electrical stimulation assisted cycling. Principal Site Investigator: J Paratz.
ACTIONS: Centre for Research Excellence in Advanced Cardio-respiratory Therapies Improving Organ Support. Principal Site Investigator: J Roberts.
Saline installation in respiratory therapy in ICU, a crossover study. Paratz J
Pneumo-INSPIRE: An international multi-centre prospective observational cohort study on nosocomial pneumonia in intensive care. Principal Site Investigator: D Koulenti.
Pharmacokinetics: A study investigating ketorolac pharmacokinetics in joint replacements. Principal Site Investigators: J Roberts, S Wallis, U Gurunathan and S Parker.
POEMSLUN: A study investigating the pharmacokinetics of enteric-coated mycophenolate sodium in lupus nephritis. Principal Site Investigators: J Roberts, J Lipman, H Aziz.
Epidemiology of Pneumonia in the Central Australian Intensive Care Unit. Principal Site Investigator: D Tsai, and J Roberts.
ECMO ((Extracorporeal Membrane Oxygenation): A study investigating the pharmacokinetics of broad-spectrum antibiotics in extracorporeal membrane oxygenation (ECMO) using plasma concentrations to optimise antibiotic therapy. Principal Site Investigators: J Roberts and S Wallis.
Antibiotic, sedative and analgesic drug pharmacokinetics during ovine extracorporeal membrane oxygenations - understanding altered pharmacokinetics to improve patient outcomes. Principal Site Investigators: J Roberts and S Wallis.
SLED: A study investigating the pharmacokinetics of vancomycin and ticarcillin-clavulanate in critically ill patients undergoing sustained low-efficiency dialysis. Principal Investigator: C Economou.
An animal in vivo study using the microdialysis technique to investigate whether inhaled antibiotics deliver optimal concentrations to the lung to improve treatment of pneumonia. Principal Site Investigators: J Dhanani, D Paterson, J Roberts.
Dosing to maximise bacterial killing and prevent resistance in ICU. Principal Site Investigators: J Roberts, J Lipman, S Wallis.
PARITY: A study investigating paracetamol in Traumatic Brain Injury. Principal Site Investigators: J Gowardman, J Roberts, J Lipman, S Wallis and M Saxena.
Antibiotic pharmacokinetics in Slow Low Efficiency Dialysis (piperacillin, meropenem and vancomycin; collaboration with the Ottawa Hospital). Principal Site Investigators: J Roberts.
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ASAP-ECMO (Extracorporeal Membrane Oxygenation): A multi-centre Australian pharmacokinetic study evaluating the pharmacokinetics of various antibiotics, antifungals, sedatives and analgesics in critically ill patients receiving extracorporeal membrane oxygenation. Principal Site Investigator: J Roberts
BLING III: A phase III randomised controlled trial of continuous beta-lactam infusion compared with intermittent beta-lactam dosing in critically ill patients. Principal Site Investigator: J Lipman
Ceftolozane/Tazobactam RRT: An observational pharmacokinetic study of Ceftolozane-Tazobactam in Intensive Care Unit in patients with and without continuous renal replacement therapy. Principal Site Investigator: J Roberts
Ceftolozane/Tazobactam EVD: A prospective observational pharmacokinetic evaluation of the plasma and cerebrospinal fluid concentrations of a single dose ceftolozane/tazobactam in infected critically ill patients with an indwelling external ventricular drain. Principal Site Investigators: J Roberts, J Lipman
Colonic Flora: Assessing the effects of antibiotic choice on gut microbiota of ICU patients - a metagenomic approach. Principal Site Investigators: D Paterson, P Harris, S Schlebusch
GUPPIE: An Observational Study to assess aspiration risk using gastric ultrasound in ventilated ICU patients prior to extubation Principal Site Investigators: S O'Donoghue, E Roach
Microsampling: Validation of microsampling versus traditional blood sampling for antibiotic pharmacokinetics. Principal Site Investigators: J Lipman, S Wallis
OASES: The Pharmacokinetics of Ceftriaxone, Meropenem, Piperacillin-Tazobactam and Vancomycin in the Cerebrospinal Fluid of Critically Ill Patients with Uninflamed Meninges. Principal Site Investigators: J Roberts, N Kumta
PATCH TRAUMA: Pre-hospital Anti-fibrinolytics for Traumatic Coagulopathy and Haemorrhage (The PATCH Study). A multi-centre randomised, double-blind, placebo-controlled trial of pre-hospital treatment with tranexamic acid for severely injured patients at risk of acute traumatic coagulopathy. Principal Site Investigators: M Reade, A Holley
PLUS: A multi-centre, blinded, randomised, controlled trial to determine whether fluid resuscitation and therapy with a “balanced” crystalloid solution (Plasma-Lyte 148®) decrease 90-day mortality in critically ill patients requiring fluid resuscitation when compared to the same treatment with 0.9% sodium chloride (saline). Principal Site Investigator: J Lipman
RESIST: Recognising Sepsis in SIRS Trial. Principal Site Investigator: K Denny
TBI Study: A Comparison of the Total and Free Cortisol Response to a Standard Short Synacthen Test in Patients with Traumatic Brain Injury. Principal Investigator: J Cohen
Synacthen Study: The free cortisol response to synacthen and other aspects of endocrine physiology in healthy participants. Principal Site Investigators: J Cohen, G Nethathe
Nicotine study: Pharmacokinetics of Transdermal Nicotine replacement therapy patches in the ICU: A prospective observational pharmacokinetic study of nicotine/cotinine concentrations in critically ill smokers receiving transdermal NRT patches. Principal Site Investigators: J Cohen, D Lui
CLONES: Clonidine at Low dosage postOperatively to Nocturnally Enhance Sleep: A randomised, double-blind, single-centre, placebo-controlled trial of low-dose clonidine infusion to improve sleep in postoperative patients in the High Dependency Unit
Completed
DALI: Defining Antibiotic Levels in Intensive care unit patients. Principal Site Investigators: J Lipman, J Roberts, S Wallis DALI: Interview with Jason Roberts and Jeffrey Lipman
ATHLOMICS: Continuous Monitoring of Acute Non-Specific Immuno-inflammatory Response using SeptiCyte®Lab to Determine the Relationship Between Inflammatory Index and Clinical Progression and Outcome Measures. Principal Site Investigator: J Lipman
CHEST: A multi-centre randomised controlled trial of fluid resuscitation with starch (6% hydroxyethyl starch 130/0.4) compared to saline (0.9% sodium chloride) in intensive care patients on mortality. Principal Site Investigator: J Lipman
ARCTIC: Augmented Renal Clearance in The Intensive Care. Principal Site Investigator: A Udy
ARCTICUS: Augmented Renal Clearance in The Intensive Care Unit: Multi-centre trial with Singapore. Principal Site Investigator: A Udy
CYTOFAB TNF alpha antagonist: A Multicentre, Randomised, Double-Blind, Placebo‑controlled Phase IIb Study to compare the Efficacy and Safety of Two Dosing Regimens of Intravenous Infusions of CytoFab™ (AZD9773) in Adult Patients With Severe Sepsis and/or Septic Shock. Principal Investigator: S O'Donoghue
RENAL: A Pharmacokinetic Substudy identifying the variability in trough antibiotic concentrations and the influence of effluent flow rates on dosing requirements for critically ill patients. Principal Investigator: J Lipman
DUST: Distal Ureteric Stone Tamsulosin: A double-blinded, placebo-controlled, randomised trial. Principal Investigators: J Furyk, K Chu
CLIP (Cryopreserved vs LIquid Platelet study): Evaluation of cryopreserved platelets for the treatment of perioperative haemorrhage. Principal Investigator: M Reade
SMARRT (SaMpling Antibiotics in Renal Replacement Therapy): Evidence-based antibiotic dosing for critically ill patients receiving renal replacement therapy. Principal Investigator: J Roberts
ANZ Clinical Trials Registration
Post RENAL: Prolonged outcome study of patients admitted to ICU who received Continuos Renal replacement therapy for Acute renal failure. Principal Investigator: J Lipman
ARISE (Australian Resuscitation In Sepsis Evaluation): A randomised controlled trial comparing early goal directed therapy to standard care for patients in septic shock. Principal Site Investigator: J Williams
IPHIVAP: Inhaled Prophylactic Heparin in Ventilator Associated Pneumonia. Principal Investigator: R Boots
BLING II: A national and international Phase IIb clinical trial of continuous β-lactam infusion compared with intermittent β-lactam dosing in critically ill patients with severe sepsis. Principal Investigator: J Lipman
ADRENAL: A randomised controlled trial of the effect of hydrocortisone on mortality in critically ill patients with septic shock. Principal Site Investigator: J Cohen
DahLIA: A randomised, double-blind, placebo controlled trial of dexmedetomidine for patients with agitation and delirium in the ICU. Principal Site Investigator: M Reade
RSVP: A Multi-centred trial to examine implications of a routine versus clinically indicated need to change giving sets for iv infusions. Principal Site Investigator: J Gowardman
MicroSOAP: Microcirculatory Shock Occurrence in Acutely ill Patients-microcirculatory alterations in ICU patients with tachycardia are associated with a substantially increased risk of in-hospital death. Principal Site Investigator: A Holley
TRANSFUSE: STandaRd Issue TrANsfusion versuS Fresher red blood cell Use in intenSive care. A multi-centre randomised double blinded phase III trial of the effect of standard issue red blood cell blood units on mortality compared to freshest available red blood cell units. Principal Investigator: M Reade. Principal Site Investigator: A Holley
Ceftriaxone in Pneumonia: Optimising ceftriaxone dosing for critically ill patients with severe pneumonia. Principal Investigators: M Cotta, J Roberts
LEVETY: Levetiracetam pharmacokinetics in critically ill patients with severe traumatic brain injury and subarachnoid haemorrhage. Principal Site Investigators: M Cotta, J Roberts