The Royal Brisbane and Women's Hospital Departments of Intensive Care Medicine, Emergency Medicine and Trauma Medicine together with the BTCCRC are site investigators for the following single and multi-centre trials.


ADRENAL: A randomised controlled trial of the effect of hydrocortisone on mortality in critically ill patients with septic shock. Principal Investigator: J Cohen

ASAP-ECMO (Extracorporeal Membrane Oxygenation): A multi-centre Australian pharmacokinetic study evaluating the pharmacokinetics of various antibiotics, antifungals, sedatives and analgesics in critically ill patients receiving extracorporeal membrane oxygenation. Principal Site Investigator: J Roberts

DahLIA: A randomised, double-blind, placebo controlled trial of dexmedetomidine for patients with agitation and delirium in the ICU. Principal Site Investigator: M Reade

RSVP: A Multi-centred trial to examine implications of a routine versus clinically indicated need to change giving sets for iv infusions. Principal Site Investigator: J Gowardman

DUST: Distal Ureteric Stone Tamsulosin: A double-blinded, placebo-controlled, randomised trial. Principal Investigators: J Furyk, K Chu

CLIP (Cryopreserved vs LIquid Platelet study): Evaluation of cryopreserved platelets for the treatment of perioperative haemorrhage. Principal Investigator: M Reade

SMARRT (SaMpling Antibiotics in Renal Replacement Therapy): Evidence-based antibiotic dosing for critically ill patients receiving renal replacement therapy. Principal Investigator: J Roberts
ANZ Clinical Trials Registration

MicroSOAP: Microcirculatory Shock Occurrence in Acutely ill Patients-microcirculatory alterations in ICU patients with tachycardia are associated with a substantially increased risk of in-hospital death. Principal Investigator: A Holley

TRANSFUSE: STandaRd Issue TrANsfusion versuS Fresher red blood cell Use in intenSive care. A multi-centre randomised double blinded phase III trial of the effect of standard issue red blood cell blood units on mortality compared to freshest available red blood cell units. Principal Investigator: M Reade. Principal Site Investigator: A Holley

Multicentre randomised controlled trial incorporating bedside lung ultrasound into the diagnosis of congestive cardiac failure in breathless older patients. Principal Site Investigator: K Chu

A randomised controlled trial of interventional versus conservative treatment of primary spontaneous pneumothorax'. Principal Site Investigator: D McAuley

T3 Trial: Triage, Treatment and Transfer of patients with stroke in emergency departments. Principal Site Investigator: J Williams

Testing the effectiveness of a targeted implementation intervention compared with passive dissemination on the uptake of key evidence-based recommended practices in the emergency department management of mild head injury in Australia: A cluster randomised trial. Principal Site Investigator: F Williamson


DALI: Defining Antibiotic Levels in Intensive care unit patients. Principal Site Investigators: J Lipman, J Roberts, S Wallis  DALI: Interview with Jason Roberts and Jeffrey Lipman

ATHLOMICS: Continuous Monitoring of Acute Non-Specific Immuno-inflammatory Response using SeptiCyte®Lab to Determine the Relationship Between Inflammatory Index and Clinical Progression and Outcome Measures. Principal Site Investigator: J Lipman

CHEST: A multi-centre randomised controlled trial of fluid resuscitation with starch (6% hydroxyethyl starch 130/0.4) compared to saline (0.9% sodium chloride) in intensive care patients on mortality. Principal Site Investigator: J Lipman

ARCTIC: Augmented Renal Clearance in The Intensive Care. Principal Site Investigator: A Udy

ARCTICUS: Augmented Renal Clearance in The Intensive Care Unit: Multi-centre trial with Singapore. Principal Site Investigator: A Udy

CYTOFAB TNF alpha antagonist: A Multicentre, Randomised, Double-Blind, Placebo‑controlled Phase IIb Study to compare the Efficacy and Safety of Two Dosing Regimens of Intravenous Infusions of CytoFab™ (AZD9773) in Adult Patients With Severe Sepsis and/or Septic Shock. Principal Investigator: S O'Donoghue

RENAL: A Pharmacokinetic Substudy identifying the variability in trough antibiotic concentrations and the influence of effluent flow rates on dosing requirements for critically ill patients. Principal Investigator: J Lipman

Post RENAL: Prolonged outcome study of patients admitted to ICU who received Continuos Renal replacement therapy  for Acute renal failure. Principal Investigator: J Lipman

ARISE (Australian Resuscitation In Sepsis Evaluation): A randomised controlled trial comparing early goal directed therapy to standard care for patients in septic shock. Principal Site Investigator: J Williams

IPHIVAP: Inhaled Prophylactic Heparin in Ventilator Associated Pneumonia. Principal Investigator: R Boots

BLING II: A national and international Phase IIb clinical trial of continuous β-lactam infusion compared with intermittent β-lactam dosing in critically ill patients with severe sepsis. Principal Investigator: J Lipman